PNPLA3
Sign in to saveAlso known as ADPN, C22orf20, iPLA(2)epsilon, patatin like phospholipase domain containing 3
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.
In the Vinony graph
Within Vinony's link graph, PNPLA3 is referenced by 8 other articles, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.
Vinony files it under EC 3.1.1 and Genes on human chromosome 22.
Its subject is documented across 6 Wikipedia language editions.
Gene data
PNPLA3- Name
- patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
- Type
- protein-coding
- Position
- 43,923,761–43,964,488 (+)
- Aliases
- ADPN, C22orf20, iPLA(2)epsilon
- Ensembl
- ENSG00000100344
- RefSeq RNA
- NM_025225.3
- RefSeq protein
- NP_079501.2
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
- Symbol
- PNPLA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:43,923,761-43,964,488
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 11883
- genetic association
- fatty liver disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/80339
- genomic end
- 44360368
- genomic start
- 43923792
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.31
- expressed in
- middle temporal gyrus
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Genomics
- Biochemistry
- Clinical relevance
- References
- Further reading
Patatin-like phospholipase domain-containing protein 3 (PNPLA3), also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.
== Function ==
Excerpted from Wikipedia’s “PNPLA3” article, available under the CC BY-SA 4.0 licence.