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afloqualone
Sign in to saveAfloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
In the Vinony graph
Vinony's link graph records 590 inbound references to afloqualone, and connects out to benzodiazepine drug, isovaleric acid and allopregnanolone.
Vinony files it under Chemical pages without DrugBank identifier, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C16H14FN3O
- Molecular weight
- 283.3 g/mol
- IUPAC name
- 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
37 papers- Coma and seizure caused by an afloqualone overdose.Pediatrics international : official journal of the Japan Pediatric Society · 2019
- Accidental afloqualone intoxication in two dogs.The Journal of veterinary medical science · 2018
- Afloqualone photosensitivity: immunogenicity of afloqualone-photomodified epidermal cells.Photochemistry and photobiology · 1994
- Afloqualone phototoxicity--photosensitized lipid peroxidative potency and its biological significance.The Tokai journal of experimental and clinical medicine · 1989
- Comparison of the myotonolytic activity of tizanidine, eperisone and afloqualone in mouse and rabbit.The Journal of international medical research · 1989
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 283.112
Show 4 more facts
- chemical formula
- C₁₆H₁₄FN₃O
- canonical SMILES
- CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF
- subject has role
- photosensitizer
- Commons category
- Afloqualone
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
== See also == Diproqualone Etaqualone Methylmethaqualone Mecloqualone Mebroqualone Cloroqualone Nitromethaqualone
Excerpted from Wikipedia’s “afloqualone” article, available under the CC BY-SA 4.0 licence.