Structure via PubChem · Public domain (PubChem)
alcaftadine
Sign in to saveAlso known as Lastacaft®, R-89674, Alcaftadina, 6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-iMidazo[2,1-b][3]benzazepine-3-carboxaldehyde, Vilasta, Alcaftadinum
Alcaftadine, sold under the brand name Lastacaft, is an antihistamine used to help prevent itching of the eyes. It is an H1 histamine receptor antagonist. It is given as an drops in the eye.
In the Vinony graph
Vinony's link graph records 3 inbound references to alcaftadine, and connects out to over-the-counter drug, (RS)-meclizine and digital object identifier.
It is catalogued under topics including Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and Drugs developed by AbbVie.
Vinony links it to 10 Wikipedia language editions.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477316420
- Drug.image
- Alcaftadine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Lastacaft
- Drug.MedlinePlus
- a611022
- Drug.DailyMedID
- Alcaftadine
- Drug.routes_of_administration
- Eye drops
- Drug.ATC_prefix
- S01
- Drug.ATC_suffix
- GX11
- Drug.legal_US
- OTC
- Drug.elimination_half life
- ~2 hrs
- Drug.CAS_number
- 147084-10-4
- Drug.PubChem
- 19371515
- Drug.IUPHAR_ligand
- 7587
- Drug.DrugBank
- DB06766
- Drug.ChemSpiderID
- 14201635
via Wikipedia infobox
Chemical data
- Formula
- C19H21N3O
- Molecular weight
- 307.4 g/mol
- IUPAC name
- 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2010
- Admin. routes
- topical
- Indications
- eye allergy, allergic conjunctivitis
via ChEMBL · EBI
Research
39 papers- Comparative assessment of alcaftadine and olopatadine for allergic conjunctivitis: a meta-analysis.Postepy dermatologii i alergologii · 2024
- Alcaftadine for the prevention of itching associated with allergic conjunctivitis.The Annals of pharmacotherapy · 2012
- Alcaftadine: a topical antihistamine for use in allergic conjunctivitis.Drugs of today (Barcelona, Spain : 1998) · 2011
- Cutaneous Calcium/Calmodulin-Dependent Protein Kinase II-γ-Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
- Alcaftadine 0.25% versus Olopatadine 0.1% in Preventing Cedar Pollen Allergic Conjunctivitis in Japan: A Randomized Study.Ocular immunology and inflammation · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 307.168
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₉H₂₁N₃O
- canonical SMILES
- CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
- World Health Organisation international non-proprietary name
- alcaftadine
- subject has role
- H1 antagonist
- Commons category
- Alcaftadine
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Pharmacology
- Adverse effects
- Pharmacokinetics
- History
- Society and culture
- Economics
- Legal status
- References
Alcaftadine, sold under the brand name Lastacaft, is an antihistamine used to help prevent itching of the eyes. It is an H1 histamine receptor antagonist. It is given as an drops in the eye.
It was approved for medical use in the United States in July 2010. It is available as a generic medication and as an over-the-counter medication.
Excerpted from Wikipedia’s “alcaftadine” article, available under the CC BY-SA 4.0 licence.