ALDH3A1

Also known as ALDH3, ALDHIII, aldehyde dehydrogenase 3 family member A1, Aldehyde dehydrogenase 3 family, member A1

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, ALDH3A1 is referenced by 26 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 17.

Its subject is documented across 7 Wikipedia language editions.

Gene data

ALDH3A1

Name: aldehyde dehydrogenase 3 family member A1
Type: protein-coding
Position: 19,737,984–19,748,943 (−)
Aliases: ALDH3, ALDHIII
Ensembl: ENSG00000108602
RefSeq RNA: NM_000691.5, NM_001135167.1, NM_001135168.1, NM_001330150.2, XM_011523731.3
RefSeq protein: NP_000682.3, NP_001128639.1, NP_001128640.1, NP_001317079.1, XP_011522033.1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].