ATF7IP
Sign in to saveAlso known as AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.
Gene data
ATF7IP- Name
- activating transcription factor 7 interacting protein
- Type
- protein-coding
- Aliases
- AM, ATF-IP, ATF7IP1, MCAF, MCAF1, p621
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010].
via MyGene.info
Gene · Ensembl
activating transcription factor 7 interacting protein
- Symbol
- ATF7IP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:14,365,439-14,502,931
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10051
- cytogenetic location
- 12p13.1
- exact match
- identifiers.org/ncbigene/55729
- genomic end
- 14651697
- genomic start
- 14518610
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.
==Interactions== ATF7IP has been shown to interact with MBD1. In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.