benserazide

Also known as Madopar®, Ro 4-4602, serazide, Ro 44602, DL-serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, DL-serine 2-(2,3,4-trihydroxybenzyl)hydrazide, benserazida, benserazidum

Benserazide is a peripherally acting aromatic L-amino acid decarboxylase or DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 431818918
Drug.image: Benserazid.svg
Drug.image_class: skin-invert-image
Drug.image2: Benserazide ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.pregnancy_AU: B3
Drug.ATC_prefix: None
Drug.index2_label: as HCl
Drug.CAS_number: 322-35-0
Drug.CAS_number2: 14919-77-8
Drug.PubChem: 2327
Drug.IUPHAR_ligand: 5150
Drug.DrugBank: DB12783
Drug.DrugBank2: DBSALT002687
Drug.ChemSpiderID: 2237
Drug.ChemSpiderID2: 25109
Drug.UNII: 762OS3ZEJU

via Wikipedia infobox

Chemical data

Formula: C10H15N3O5
Molecular weight: 257.24 g/mol
IUPAC name: 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O
InChIKey: BNQDCRGUHNALGH-UHFFFAOYSA-N
XLogP: -1.3
Polar surface area: 148 Å²
H-bond donors: 7
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: restless legs syndrome, Parkinson disease

via ChEMBL · EBI

Research

1,641 papers

via PubMed

Wikidata facts

Subclass of: chemical compound
Has part: carbon
Mass: 257.101171
Has use: medication

Show 5 more facts

chemical formula: C₁₀H₁₅N₃O₅
canonical SMILES: C1=CC(=C(C(=C1CNNC(=O)C(CO)N)O)O)O
World Health Organisation international non-proprietary name: benserazide
subject has role: dopaminergic
found in taxon: Streptomyces

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

3 sections

Contents

Medical uses
Pharmacology
References

Benserazide is a peripherally acting aromatic L-amino acid decarboxylase or DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.

Benserazide is a therapeutic alternative on the World Health Organization's List of Essential Medicines.

Excerpted from Wikipedia’s “benserazide” article, available under the CC BY-SA 4.0 licence.

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