Structure via PubChem · Public domain (PubChem)
berbamine
Sign in to saveBerbamine is a calcium channel blocker.
In the Vinony graph
Vinony's link graph records 322 inbound references to berbamine, and connects out to valproic acid, (RS)-baclofen and voltage-gated sodium channel.
Vinony files it under Calcium channel blockers, Diphenyl ethers and ECHA InfoCard ID from Wikidata.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C37H40N2O6
- Molecular weight
- 608.7 g/mol
- IUPAC name
- (1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
- SMILES
- CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
- InChIKey
- DFOCUWZXJBAUSQ-URLMMPGGSA-N
- XLogP
- 6.1
- Polar surface area
- 72.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
343 papers- Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer.Pharmacological research · 2025
- Berbamine alleviates neuropathic pain via suppressing spinal TMEM34/SGK1/FOXO3 axis.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025
- Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
- Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers.International journal of molecular sciences · 2022
- Berbamine prevents SARS-CoV-2 entry and transmission.iScience · 2024
via PubMed
Wikidata facts
- Subclass of
- isoquinoline alkaloid
- Mass
- 608.288637
Show 5 more facts
- canonical SMILES
- CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
- chemical formula
- C₃₇H₄₀N₂O₆
- found in taxon
- Menispermum dauricum
- subject has role
- calcium channel blocker
- isomeric SMILES
- CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Berbamine is a calcium channel blocker.
==References==
Excerpted from Wikipedia’s “berbamine” article, available under the CC BY-SA 4.0 licence.
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