carbinoxamine
Sign in to saveAlso known as paracarbinoxamine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine, carbinoxamine base, (+-)-carbinoxamine, 2-(P-chloro-alpha-(2-(dimethylamino)Ethoxy)benzyl)pyridine, {2-[(4-chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine, (+-)-Carbinoxamine, Paracarbinoxamine
Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.
Research
75 papers- Carbinoxamine.2012
- Carbinoxamine.2006
- Synthesis of carbinoxamine via α-C(sp(3))-H 2-pyridylation of O, S or N-containing compounds enabled by non-D-A-type super organoreductants and sulfoxide- or sulfide HAT reagents.Chemical science · 2022
- Studies on the in vitro ion exchange kinetics and thermodynamics and in vivo pharmacokinetics of the carbinoxamine-resin complex.International journal of pharmaceutics · 2020
- Capillary GLC assay for carbinoxamine and hydrocodone in human serum using nitrogen-sensitive detection.Journal of pharmaceutical sciences · 1983
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Encyclopedic overview
5 sectionsContents
- Society and culture
- Brand names
- Side effects
- See also
- References
Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.
It was patented in 1947 and came into medical use in 1953. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. Carbinoxamine is available in various countries around the world by itself, combined with decongestants such as pseudoephedrine, and also with other ingredients including paracetamol, aspirin, and codeine.
Excerpted from Wikipedia’s “carbinoxamine” article, available under the CC BY-SA 4.0 licence.