CCR7

Also known as BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7

protein-coding gene in the species Homo sapiens

Gene data

CCR7

Name: C-C motif chemokine receptor 7
Type: protein-coding
Position: 40,551,081–40,565,472 (−)
Aliases: BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Ensembl: ENSG00000126353
RefSeq RNA: NM_001301714.2, NM_001301716.2, NM_001301717.2, NM_001301718.2, NM_001838.4
RefSeq protein: NP_001288643.1, NP_001288645.1, NP_001288646.1, NP_001288647.1, NP_001829.1

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014].