CD244
Sign in to saveAlso known as 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.
Gene data
CD244- Name
- CD244 molecule
- Type
- protein-coding
- Aliases
- 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
via MyGene.info
Gene · Ensembl
CD244 molecule
- Symbol
- CD244
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:160,829,075-160,862,904
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9493
- exact match
- identifiers.org/ncbigene/51744
- genomic end
- 160862887
- genomic start
- 160799950
- cytogenetic location
- 1q23.3
via Wikidata · CC0
~4 min read
Article
9 sectionsContents
- Gene
- Structure
- Function
- Role of CD244 in viral infections
- Role of CD244 in cancer
- See also
- References
- Further reading
- External links
CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene.
CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells. CD244 plays a role in the regulation of the immune system.