CD48 molecule
Sign in to saveAlso known as BCM1 surface antigen, SLAMF2, leukocyte antigen MEM-102, CD48, TCT.1, SLAM family member 2, CD48 antigen (B-cell membrane protein), B-lymphocyte activation marker BLAST-1
CD48 antigen (cluster of differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.
Protein · UniProt
CD48 antigen
- Gene
- CD48
- Organism
- Homo sapiens (Human)
- Length
- 243 aa
- Molecular mass
- 27,683 Da
- Evidence
- 1: Evidence at protein level
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation (PubMed:12007789, PubMed:19494291, PubMed:27249817, PubMed:9841922). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cy…
Swiss-Prot (reviewed) · via UniProt
Research
460 papers- CD48 is a key molecule of immunomodulation affecting prognosis in glioma.OncoTargets and therapy · 2019
- Identification of the 2B4 molecule as a counter-receptor for CD48.Journal of immunology (Baltimore, Md. : 1950) · 1998
- CD48: A co-stimulatory receptor of immunity.The international journal of biochemistry & cell biology · 2011
- Roles of CD48 in regulating immunity and tolerance.Clinical immunology (Orlando, Fla.) · 2016
- Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor.PLoS pathogens · 2019
via PubMed
~3 min read
Article
10 sectionsContents
- Structure
- Interactions
- Function
- Cell distribution
- T-cell activation
- Clinical significance
- See also
- [[Reference]]s
- Further reading
- External links
CD48 antigen (cluster of differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.
CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells.