CD36 molecule
Sign in to saveAlso known as Thrombospondin receptor, Platelet collagen receptor, platelet glycoprotein 4, GPIV, CD36 antigen (collagen type I receptor, thrombospondin receptor), glycoprotein IIIb, cluster determinant 36, FAT
CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium f
Protein · UniProt
Platelet glycoprotein 4
- Gene
- CD36
- Organism
- Homo sapiens (Human)
- Length
- 472 aa
- Molecular mass
- 53,053 Da
- Evidence
- 1: Evidence at protein level
Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long- and very long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on corecep…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
Show 1 more fact
- Commons category
- Fatty taste receptors
Sources (3)
via Wikidata · CC0
~15 min read
Article
24 sectionsContents
- Structure
- Primary
- Tertiary
- Posttranslational modification
- Protein-protein interactions
- Genetics
- Tissue distribution
- Function
- Clinical significance
- Malaria
- CD36 deficiency and alloimmune thrombocytopenia
- Blood pressure
- Fatty acid uptake
- Tuberculosis
- Toxoplasmosis
- Obesity
- Establishment of cellular senescence
- Cancer
- Interactions
- Related proteins
- See also
- References
- Further reading
- External links
CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral membrane protein found on the surface of many cell types in vertebrate animals. It imports fatty acids inside cells and is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids.
Work in genetically modified rodents suggest a role for CD36 in fatty acid metabolism, heart disease, taste, and dietary fat processing in the intestine. It may be involved in glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer's disease and various cancers, mostly of epithelial origin (breast, prostate, ovary, and colon) and also for hepatic carcinoma and gliomas.