CHD4
Sign in to saveAlso known as CHD-4, Mi-2b, Mi2-BETA, chromodomain helicase DNA binding protein 4, SIHIWES
Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.
Gene data
CHD4- Name
- chromodomain helicase DNA binding protein 4
- Type
- protein-coding
- Position
- 6,570,081–6,614,982 (−)
- Aliases
- CHD-4, Mi-2b, Mi2-BETA, SIHIWES
- Ensembl
- ENSG00000111642
- RefSeq RNA
- NM_001273.5, NM_001297553.2, NM_001363606.2
- RefSeq protein
- NP_001264.2, NP_001284482.1, NP_001350535.1
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
chromodomain helicase DNA binding protein 4
- Symbol
- CHD4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:6,570,081-6,614,982
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 68175
- exact match
- identifiers.org/ncbigene/1108
- genomic end
- 6614524
- genomic start
- 6570082
- cytogenetic location
- 12p13.31
via Wikidata · CC0
~1 min read
Article
6 sectionsContents
- Function
- Interactions
- Clinical
- References
- External links
- Further reading
Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex.
== Function ==