CPA3
Sign in to saveAlso known as MC-CPA, carboxypeptidase A3
Carboxypeptidase A3 (mast cell carboxypeptidase A), also known as CPA3, is an enzyme which in humans is encoded by the CPA3 gene. The "CPA3" gene expression has only been detected in mast cells and mast-cell-like lines, and CPA3 is located in secretory granules. CPA3 is one of 8-9 members of the A/B subfamily that includes the well-studied pancreatic enzymes carboxypeptidase A1 (CPA1), carboxypeptidase A2 (CPA2), and carboxypeptidase B. This subfamily includes 6 carboxypeptidase A-like enzymes, numbered 1-6. The enzyme now called CPA3 was originally named mast cell carboxypeptidase A, and anot
In the Vinony graph
Within Vinony's link graph, CPA3 is referenced by 4 other articles, and connects out to PubMed, mast cell and human chromosome 3.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 4 Wikipedia language editions.
Gene data
CPA3- Name
- carboxypeptidase A3
- Type
- protein-coding
- Position
- 148,865,278–148,898,572 (+)
- Aliases
- MC-CPA
- Ensembl
- ENSG00000163751
- RefSeq RNA
- NM_001870.4
- RefSeq protein
- NP_001861.2
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
carboxypeptidase A3
- Symbol
- CPA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:148,865,278-148,898,572
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 122138
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1359
- chromosome
- human chromosome 3
- genomic start
- 148865296
- genomic end
- 148897203
- cytogenetic location
- 3q24
Sources (3)
via Wikidata · CC0
~3 min read
Encyclopedic overview
9 sectionsContents
- Structure
- Gene
- Protein
- Function
- Clinical significance
- Interactions
- References
- External links
- Further reading
Carboxypeptidase A3 (mast cell carboxypeptidase A), also known as CPA3, is an enzyme which in humans is encoded by the CPA3 gene. The "CPA3" gene expression has only been detected in mast cells and mast-cell-like lines, and CPA3 is located in secretory granules. CPA3 is one of 8-9 members of the A/B subfamily that includes the well-studied pancreatic enzymes carboxypeptidase A1 (CPA1), carboxypeptidase A2 (CPA2), and carboxypeptidase B. This subfamily includes 6 carboxypeptidase A-like enzymes, numbered 1-6. The enzyme now called CPA3 was originally named mast cell carboxypeptidase A, and another protein was initially called CPA3. A gene nomenclature committee renamed mast cell carboxypeptidase A as CPA3, and the original CPA3 reported by Huang et al. became CPA4 to reflect the order of their discovery.
==Structure==
Excerpted from Wikipedia’s “CPA3” article, available under the CC BY-SA 4.0 licence.