CPN1
Sign in to saveAlso known as CPN, SCPN, carboxypeptidase N subunit 1
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.
Gene data
CPN1- Name
- carboxypeptidase N subunit 1
- Type
- protein-coding
- Aliases
- CPN, SCPN
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
carboxypeptidase N subunit 1
- Symbol
- CPN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:100,041,105-100,081,907
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CPN1 PDB 2nsm.png
Show 5 more facts
- HomoloGene ID
- 1002
- exact match
- identifiers.org/ncbigene/1369
- genomic end
- 100081869
- genomic start
- 101801950
- cytogenetic location
- 10q24.2
Sources (4)
via Wikidata · CC0
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Article
3 sectionsContents
- References
- External links
- Further reading
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.