CPN1
Sign in to saveAlso known as CPN, SCPN, carboxypeptidase N subunit 1
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.
In the Vinony graph
Within Vinony's link graph, CPN1 is referenced by 3 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 10.
Its subject is documented across 4 Wikipedia language editions.
Gene data
CPN1- Name
- carboxypeptidase N subunit 1
- Type
- protein-coding
- Position
- 100,041,105–100,081,907 (−)
- Aliases
- CPN, SCPN
- Ensembl
- ENSG00000120054
- RefSeq RNA
- NM_001308.3
- RefSeq protein
- NP_001299.1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
carboxypeptidase N subunit 1
- Symbol
- CPN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:100,041,105-100,081,907
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CPN1 PDB 2nsm.png
Show 7 more facts
- HomoloGene ID
- 1002
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1369
- genomic end
- 100081869
- genomic start
- 101801950
- chromosome
- human chromosome 10
- cytogenetic location
- 10q24.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- External links
- Further reading
Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.
Excerpted from Wikipedia’s “CPN1” article, available under the CC BY-SA 4.0 licence.