diphenylpyraline

Also known as diphenylpyralamine, 4-(benzhydryloxy)-N-methylpiperidine, 1-methyl-4-hydroxypiperidine benzhydryl ether, 4-(benzhydryloxy)-1-methylpiperidine, 1-methyl-4-piperidyl benzhydryl ether

Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.

In the Vinony graph

Vinony's link graph records 1,089 inbound references to diphenylpyraline, and connects out to atropine, Anatomical Therapeutic Chemical Classification System and histamine antagonist.

It sits within the topics Diphenylmethanol ethers, Drugs with non-standard legal status and ECHA InfoCard ID from Wikidata.

Vinony links it to 10 Wikipedia language editions.

Chemical data

Formula: C19H23NO
Molecular weight: 281.4 g/mol
IUPAC name: 4-benzhydryloxy-1-methylpiperidine

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: oral
Indications: allergic disease

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 281.178
Has use: medication

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chemical formula: C₁₉H₂₃NO
canonical SMILES: CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3
World Health Organisation international non-proprietary name: diphenylpyraline
defined daily dose: 10.0
Commons category: Diphenylpyraline

Sources (3)

via Wikidata · CC0

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