DRD2
Sign in to saveAlso known as D2DR, D2R, dopamine receptor D2
protein-coding gene in the species Homo sapiens
Gene data
DRD2- Name
- dopamine receptor D2
- Type
- protein-coding
- Position
- 113,409,021–113,476,402 (−)
- Aliases
- D2DR, D2R
- Ensembl
- ENSG00000149295
- RefSeq RNA
- NM_000795.4, NM_001440368.1, NM_016574.4, XM_017017296.3, XM_047426511.1
- RefSeq protein
- NP_000786.1, NP_001427297.1, NP_057658.2, XP_016872785.1, XP_047282467.1
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
dopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/GoG-protein alpha-subunit bindingG protein-coupled receptor activityG protein-coupled receptor activitydopamine neurotransmitter receptor activitydopamine neurotransmitter receptor activity
Pathways
Rap1 signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Gap junction - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)Signal TransductionSignaling by GPCR
via MyGene.info
Gene · Ensembl
dopamine receptor D2
- Symbol
- DRD2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:113,409,021-113,476,402
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 7jvr Dopamine receptor D2.png
Show 10 more facts
- exact match
- identifiers.org/ncbigene/1813
- HomoloGene ID
- 22561
- found in taxon
- Homo sapiens
- genomic end
- 113346413
- genomic start
- 113409605
- chromosome
- human chromosome 11
- cytogenetic location
- 11q23.2
- expressed in
- ventral tegmental area
- Commons category
- DRD2
- genetic association
- major depressive disorder
Sources (7)
via Wikidata · CC0