DRD2
Sign in to saveAlso known as D2DR, D2R, dopamine receptor D2
protein-coding gene in the species Homo sapiens
Gene data
DRD2- Name
- dopamine receptor D2
- Type
- protein-coding
- Position
- 113,409,605–113,476,402 (−)
- Aliases
- D2DR, D2R
- Ensembl
- ENSG00000149295
- RefSeq RNA
- NM_000795.4, NM_001440368.1, NM_016574.4, XM_017017296.3, XM_047426511.1
- RefSeq protein
- NP_000786.1, NP_001427297.1, NP_057658.2, XP_016872785.1, XP_047282467.1
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
dopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/GoG-protein alpha-subunit bindingG protein-coupled receptor activityG protein-coupled receptor activitydopamine neurotransmitter receptor activitysignaling receptor binding
Pathways
Rap1 signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Gap junction - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)Signal TransductionSignaling by GPCR
via MyGene.info
Gene · Ensembl
dopamine receptor D2
- Symbol
- DRD2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:113,409,021-113,476,402
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 7jvr Dopamine receptor D2.png
Show 6 more facts
- exact match
- identifiers.org/ncbigene/1813
- HomoloGene ID
- 22561
- genomic end
- 113346413
- genomic start
- 113409605
- cytogenetic location
- 11q23.2
- Commons category
- DRD2
Sources (7)
via Wikidata · CC0
Connections
Q180686
Entity
G protein-coupled recepteishon
Entity
G protein
Entity
ligand
Entity
Ensembl genome database project
Entity
dopamine receptor
Entity
Dopamine receptor D3
Protein
alpha-2 adrenergic receptor
Entity
GHSR
Gene
NCS1
Gene
protein
Entity
Wikidata
Entity
gene
Entity
chromosome
Entity
autism
Entity
schizophrenia
Entity
Parkinson's disease
Entity
public domain
Entity
digital object identifier
Entity
dopamine
Entity