ECEL1
Sign in to saveAlso known as DA5D, DINE, ECEX, XCE, endothelin converting enzyme-like 1, endothelin converting enzyme like 1
Endothelin-converting enzyme-like 1 is a protein that in humans is encoded by the ECEL1 gene.
In the Vinony graph
Within Vinony's link graph, ECEL1 is referenced by 2 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 7 Wikipedia language editions.
Gene data
ECEL1- Name
- endothelin converting enzyme like 1
- Type
- protein-coding
- Position
- 232,479,825–232,489,045 (−)
- Aliases
- DA5D, DINE, ECEX, XCE
- Ensembl
- ENSG00000171551
- RefSeq RNA
- NM_001290787.2, NM_004826.4
- RefSeq protein
- NP_001277716.1, NP_004817.2
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
endothelin converting enzyme like 1
- Symbol
- ECEL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:232,479,825-232,489,045
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 3549
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9427
- genomic end
- 232487834
- genomic start
- 233344537
- chromosome
- human chromosome 2
- cytogenetic location
- 2q37.1
- expressed in
- caudate nucleus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Endothelin-converting enzyme-like 1 is a protein that in humans is encoded by the ECEL1 gene.
This gene encodes a member of the neutral endopeptidase (NEP)-related family. It is expressed specifically in the nervous system. The gene disruption in mouse embryonic stem cells results in neonatal lethality due to respiratory failure shortly after birth. Based on the specific expression of this gene and the phenotype of the gene deficiency in mouse embryos, it is suggested that the protein encoded by this gene play a critical role in the nervous regulation of the respiratory system.
Excerpted from Wikipedia’s “ECEL1” article, available under the CC BY-SA 4.0 licence.