EREG

Also known as EPR, ER, Ep, epiregulin

Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene.

Gene data

EREG

Name: epiregulin
Type: protein-coding
Aliases: EPR, ER, Ep

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015].

via MyGene.info

Gene · Ensembl

epiregulin

Symbol: EREG
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:74,365,137-74,388,749
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Epl.pdb.png

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HomoloGene ID: 1097
exact match: identifiers.org/ncbigene/2069
genomic end: 74388749
genomic start: 74365145
cytogenetic location: 4q13.3

Sources (6)

via Wikidata · CC0

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Article

4 sections

Contents

Structure
Function
References
Further reading

Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene.

== Structure == Epiregulin consists of 46 amino acid residues. Its secondary structure contains approximately 30 percent of β-sheet in the strand. Some of the residues form loops and turns due to the hydrogen bonding. The percentage of β-sheet in epiregulin depends on the domain and the secondary structures that they occupy. The polymeric molecules of epiregulin has the formula weight of 5280.1 g/mol with a polypeptide(L), a polymer type.