EIF4E
Sign in to saveAlso known as EIF4F, eIF-4E, eukaryotic translation initiation factor 4E, AUTS19, CBP, EIF4E1, EIF4EL1
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the EIF4E gene. eIF4E plays a central role in translation initiation and is involved in regulating protein synthesis. Its mRNA cap-binding activity influences a range of biological processes and disease states, making it an important target for therapeutic development, particularly in disorders characterized by aberrant protein production.
Gene data
EIF4E- Name
- eukaryotic translation initiation factor 4E
- Type
- protein-coding
- Position
- 98,878,761–98,929,150 (−)
- Aliases
- AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
- Ensembl
- ENSG00000151247
- RefSeq RNA
- NM_001130678.4, NM_001130679.3, NM_001331017.2, NM_001968.5
- RefSeq protein
- NP_001124150.1, NP_001124151.1, NP_001317946.1, NP_001959.1
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 4E
- Symbol
- EIF4E
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:98,876,654-98,929,925
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein EIF4E PDB 1ej1.png
Show 5 more facts
- HomoloGene ID
- 123817
- exact match
- identifiers.org/ncbigene/1977
- genomic end
- 98929133
- genomic start
- 98879276
- cytogenetic location
- 4q23
via Wikidata · CC0
~15 min read
Article
18 sectionsContents
- Discovery
- Structure
- Function
- Cap-dependent translation initiation
- mRNA Export
- RNA processing
- Regulation
- Translational repression
- Gene expression and RNA stability
- Phosphorylation
- Partner proteins
- Cellular localization
- Role in cancer
- Interactions
- See also
- References
- Further reading
- External links
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the EIF4E gene. eIF4E plays a central role in translation initiation and is involved in regulating protein synthesis. Its mRNA cap-binding activity influences a range of biological processes and disease states, making it an important target for therapeutic development, particularly in disorders characterized by aberrant protein production.
== Discovery == eIF4E was discovered as a cytoplasmic Messenger RNA cap binding protein functioning in translation by Filipowicz et al. In 1976. Two years later, in 1978, Sonenberg et al. confirmed Filipowicz et al.'s findings by repeating the same experiments and adding a crosslinking chemical to increase the stability of the mRNA-protein complex. This was the foundation for our understanding of eukaryotic cap-dependent translation initiation. These findings have been confirmed by numerous scientists and reviewed in many articles that confirmed eIF4E binds the mRNA cap to facilitate translation initiation in eukaryotes.