FOLR2
Sign in to saveAlso known as BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.
In the Vinony graph
Within Vinony's link graph, FOLR2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
FOLR2- Name
- folate receptor beta
- Type
- protein-coding
- Position
- 72,216,601–72,221,957 (+)
- Aliases
- BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, FRbeta
- Ensembl
- ENSG00000165457
- RefSeq RNA
- NM_000803.5, NM_001113534.2, NM_001113535.2, NM_001113536.2, XM_005273856.5
- RefSeq protein
- NP_000794.3, NP_001107006.1, NP_001107007.1, NP_001107008.1, XP_005273913.1
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
folate receptor beta
- Symbol
- FOLR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:72,216,601-72,221,957
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 627
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2350
- genomic end
- 71932994
- genomic start
- 71927645
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.4
- expressed in
- rectum
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence identity with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.
Excerpted from Wikipedia’s “FOLR2” article, available under the CC BY-SA 4.0 licence.