F2RL3

Also known as PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

In the Vinony graph

Vinony's link graph records 488 inbound references to F2RL3, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

Vinony files it under Genes on human chromosome 19, G protein-coupled receptors and Receptors.

Vinony links it to 5 Wikipedia language editions.

Gene data

F2RL3

Name: F2R like thrombin or trypsin receptor 3
Type: protein-coding
Position: 16,888,844–16,892,606 (+)
Aliases: PAR4
Ensembl: ENSG00000127533
RefSeq RNA: NM_003950.4
RefSeq protein: NP_003941.2

This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016].

Pathways

Rap1 signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Complement and coagulation cascades - Homo sapiens (human)Platelet activation - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Hemostasis Hemostasis Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)

via MyGene.info

Gene · Ensembl

F2R like thrombin or trypsin receptor 3

Symbol: F2RL3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:16,888,844-16,892,606
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 36148
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9002
genomic end: 17003417
genomic start: 16888999
chromosome: human chromosome 19
cytogenetic location: 19p13.11
expressed in: transverse colon

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
See also
References
Further reading

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

== Function ==

Excerpted from Wikipedia’s “F2RL3” article, available under the CC BY-SA 4.0 licence.