THBS2
Sign in to saveAlso known as TSP2, thrombospondin 2
Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.
In the Vinony graph
Vinony's link graph records 8 inbound references to THBS2, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.
It sits within the topics Genes on human chromosome 6 and Thrombospondins.
Vinony links it to 6 Wikipedia language editions.
Gene data
THBS2- Name
- thrombospondin 2
- Type
- protein-coding
- Position
- 169,215,780–169,254,060 (−)
- Aliases
- EDSCLL3, TSP2
- Ensembl
- ENSG00000186340
- RefSeq RNA
- NM_001381939.1, NM_001381940.1, NM_001381941.1, NM_001381942.1, NM_003247.5
- RefSeq protein
- NP_001368868.1, NP_001368869.1, NP_001368870.1, NP_001368871.1, NP_003238.2
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
thrombospondin 2
- Symbol
- THBS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:169,215,780-169,254,060
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein THBS2 PDB 1yo8.png
Show 7 more facts
- HomoloGene ID
- 2438
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7058
- genomic start
- 169615875
- chromosome
- human chromosome 6
- genomic end
- 169654139
- cytogenetic location
- 6q27
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.
Excerpted from Wikipedia’s “THBS2” article, available under the CC BY-SA 4.0 licence.