THBS2

Also known as TSP2, thrombospondin 2

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.

Gene data

THBS2

Name: thrombospondin 2
Type: protein-coding
Position: 169,215,780–169,254,060 (−)
Aliases: EDSCLL3, TSP2
Ensembl: ENSG00000186340
RefSeq RNA: NM_001381939.1, NM_001381940.1, NM_001381941.1, NM_001381942.1, NM_003247.5
RefSeq protein: NP_001368868.1, NP_001368869.1, NP_001368870.1, NP_001368871.1, NP_003238.2

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

cell adhesion negative regulation of angiogenesis negative regulation of angiogenesis negative regulation of angiogenesis positive regulation of synapse assembly endothelial cell-cell adhesion

Molecular function

extracellular matrix structural constituent calcium ion binding protein binding heparin binding heparin binding

Cellular component

extracellular region extracellular region extracellular region basement membrane extracellular matrix extracellular matrix extracellular matrix platelet alpha granule

Pathways

Phagosome - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)ECM-receptor interaction - Homo sapiens (human)Malaria - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Signal Transduction Disease Signaling by PDGF Diseases of glycosylation

via MyGene.info

Gene · Ensembl

thrombospondin 2

Symbol: THBS2
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:169,215,780-169,254,060
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein THBS2 PDB 1yo8.png

Show 5 more facts

HomoloGene ID: 2438
exact match: identifiers.org/ncbigene/7058
genomic start: 169615875
genomic end: 169654139
cytogenetic location: 6q27

Sources (3)

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Further reading

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.