Structure via PubChem · Public domain (PubChem)
forodesine
Sign in to saveAlso known as BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H, (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol
Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
In the Vinony graph
Vinony's link graph records 5 inbound references to forodesine, and connects out to digital object identifier, chemical formula and molar mass.
Vinony files it under Chemical pages without DrugBank identifier, Drugs missing an ATC code and Drugs with no legal status.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C11H14N4O4
- Molecular weight
- 266.25 g/mol
- IUPAC name
- 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
- SMILES
- C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
- InChIKey
- IWKXDMQDITUYRK-KUBHLMPHSA-N
- XLogP
- -2.3
- Polar surface area
- 130 Ų
- H-bond donors
- 6
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2017
- Indications
- B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, leukemia, lymphoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 266.102
Show 4 more facts
- chemical formula
- C₁₁H₁₄N₄O₄
- isomeric SMILES
- C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
- canonical SMILES
- C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
- Commons category
- Immucillin H
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
Forodesine was originally discovered by Vern Schramm's laboratory at the Albert Einstein College of Medicine in New York and Industrial Research Limited in New Zealand.
Excerpted from Wikipedia’s “forodesine” article, available under the CC BY-SA 4.0 licence.