فورودسین

Also known as BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H, (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol, Forodesine, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol

Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).

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It sits within the topics Chemical pages without DrugBank identifier, Drugs missing an ATC code and Drugs with no legal status.

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Chemical data

Formula: C11H14N4O4
Molecular weight: 266.25 g/mol
IUPAC name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
InChIKey: IWKXDMQDITUYRK-KUBHLMPHSA-N
XLogP: -2.3
Polar surface area: 130 Å²
H-bond donors: 6
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2017
Indications: B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, leukemia, lymphoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 266.102

Show 4 more facts

chemical formula: C₁₁H₁₄N₄O₄
isomeric SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
canonical SMILES: C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
Commons category: Immucillin H

Sources (2)

via Wikidata · CC0