forodesina

Also known as BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H, (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol, Forodesine, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol

composto chimico

In the Vinony graph

Vinony's link graph records 5 inbound references to forodesina, and connects out to digital object identifier, chemical formula and molar mass.

It is catalogued under topics including Chemical pages without DrugBank identifier, Drugs missing an ATC code and Drugs with no legal status.

Vinony links it to 8 Wikipedia language editions.

Chemical data

Formula: C11H14N4O4
Molecular weight: 266.25 g/mol
IUPAC name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
InChIKey: IWKXDMQDITUYRK-KUBHLMPHSA-N
XLogP: -2.3
Polar surface area: 130 Å²
H-bond donors: 6
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2017
Indications: B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, leukemia, lymphoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 266.102

Show 4 more facts

chemical formula: C₁₁H₁₄N₄O₄
isomeric SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
canonical SMILES: C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
Commons category: Immucillin H

Sources (2)

via Wikidata · CC0

Article · Italiano

Forodesina è un farmaco inibitore analogo allo stato di transizione per la fosforilasi dei nucleosidi purinici, studiata per il trattamento di pazienti con leucemia linfoblastica acuta a cellule T (T-ALL) e a cellule B (B-ALL). Originariamente fu scoperta dal laboratorio di presso l'Albert Einstein College of Medicine di New York e Industrial Research Limited in Nuova Zelanda. Viene sviluppata dalla casa farmaceutica e progettata per essere un potente ed efficace citocida nei confronti di cellule neoplastiche ed ha mostrato un’attività clinica positiva in pazienti con recidiva / refrattaria di neoplasia delle cellule T.

Abstract from DBpedia / Wikipedia · CC BY-SA