Immucillin-H

Also known as BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, (2R,3R,4S,5S)-2-(hydroxymethyl)-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol, Forodesine, (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol

chemische Verbindung

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Vinony's link graph records 5 inbound references to Immucillin-H, and connects out to digital object identifier, chemical formula and molar mass.

It sits within the topics Chemical pages without DrugBank identifier, Drugs missing an ATC code and Drugs with no legal status.

Vinony links it to 8 Wikipedia language editions.

Chemical data

Formula: C11H14N4O4
Molecular weight: 266.25 g/mol
IUPAC name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
InChIKey: IWKXDMQDITUYRK-KUBHLMPHSA-N
XLogP: -2.3
Polar surface area: 130 Å²
H-bond donors: 6
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2017
Indications: B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, leukemia, lymphoma

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 266.102

Show 4 more facts

chemical formula: C₁₁H₁₄N₄O₄
isomeric SMILES: C1=C(C2=C(N1)C(=O)N=CN2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
canonical SMILES: C1=C(C2=C(N1)C(=O)N=CN2)C3C(C(C(N3)CO)O)O
Commons category: Immucillin H

Sources (2)

via Wikidata · CC0

Article · Deutsch

Immucillin-H, Forodesin INN ( Hersteller: BioCryst Pharmaceuticals) ist ein neuartiger Wirkstoff für die gezielte Therapie von bösartigen hämatologischen Erkrankungen, insbesondere der akuten T-Zell-Leukämie (T-ALL). Immucillin-H gehört zur Gruppe der PNP-Inhibitoren und wird derzeit in verschiedenen klinischen Studien auf seine Sicherheit und Wirksamkeit getestet.

Abstract from DBpedia / Wikipedia · CC BY-SA