Galactokinase
Sign in to saveAlso known as IPR000705, ATP:D-galactose-1-phosphotransferase, ATP:D-galactose 1-phosphotransferase, galactokinase (phosphorylating)
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.
In the Vinony graph
Vinony's link graph records 429 inbound references to Galactokinase, and connects out to nucleotide, phosphates and UDP-glucose 4-epimerase.
Vinony files it under EC 2.7.1, Genes on human chromosome 15 and Genes on human chromosome 17.
Vinony links it to 18 Wikipedia language editions.
Key facts
- Protein.Name
- Galactokinase 2
- Protein.caption
- Cartoon structure of a human galactokinase 1 monomer in complex with galactose (red) and an ATP analogue (orange). A magnesium ion is visible as a green sphere. (From )
- Protein.image
- Galactokinase 1 1WUU.png
- Protein.HGNCid
- 4119
- Protein.Symbol
- GALK2
- Protein.AltSymbols
- GALK
- Protein.EntrezGene
- 2585
- Protein.OMIM
- 137028
- Protein.RefSeq
- NM_002044
- Protein.UniProt
- Q01415
- Protein.ECnumber
- 2.7.1.6
- Protein.Chromosome
- 15
- Protein.Arm
- q
- Protein.Band
- 23
- Protein.LocusSupplementaryData
- -q25
via Wikipedia infobox
Research
1,209 papers- Galactokinase promiscuity: a question of flexibility?Biochemical Society transactions · 2016
- Hereditary galactosemia.Metabolism: clinical and experimental · 2018
- Galactokinase: structure, function and role in type II galactosemia.Cellular and molecular life sciences : CMLS · 2004
- [Galactokinase deficiency].Ryoikibetsu shokogun shirizu · 1998
- Galactokinase deficiency: lessons from the GalNet registry.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
via PubMed
Wikidata facts
- Subclass of
- transferase
- Image
- Galactokinase 1 1WUU.png
Show 1 more fact
- EC enzyme number
- 2.7.1.6
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Sugar specificity
- Mechanism
- Biological function
- Disease relevance
- References
- External links
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.
==Structure==
Excerpted from Wikipedia’s “Galactokinase” article, available under the CC BY-SA 4.0 licence.