Galactokinase
Also known as IPR000705, ATP:D-galactose-1-phosphotransferase, ATP:D-galactose 1-phosphotransferase, galactokinase (phosphorylating)
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.
Key facts
- Protein.Name
- Galactokinase 2
- Protein.caption
- Cartoon structure of a human galactokinase 1 monomer in complex with galactose (red) and an ATP analogue (orange). A magnesium ion is visible as a green sphere. (From )
- Protein.image
- Galactokinase 1 1WUU.png
- Protein.HGNCid
- 4119
- Protein.Symbol
- GALK2
- Protein.AltSymbols
- GALK
- Protein.EntrezGene
- 2585
- Protein.OMIM
- 137028
- Protein.RefSeq
- NM_002044
- Protein.UniProt
- Q01415
- Protein.ECnumber
- 2.7.1.6
- Protein.Chromosome
- 15
~5 min read
Article
7 sectionsContents
- Structure
- Sugar specificity
- Mechanism
- Biological function
- Disease relevance
- References
- External links
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.
==Structure==