glucuronide

Also known as glucuronoside, glucuronides, glucuronosides

thumb|right|150px|Morphine-6-glucuronide, a major metabolite of [[morphine]] A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. The glucuronides belong to the glycosides.

Research

23,140 papers

Acyl glucuronide reactivity in perspective.Drug discovery today · 2020
Acyl glucuronide metabolites: Implications for drug safety assessment.Toxicology letters · 2017
Acyl glucuronide drug metabolites: toxicological and analytical implications.Therapeutic drug monitoring · 2003
Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.Drug metabolism and disposition: the biological fate of chemicals · 2024
Glucuronidation: driving factors and their impact on glucuronide disposition.Drug metabolism reviews · 2017

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Wikidata facts

Image: Glucuronide group.svg

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CXSMILES: O1[C@@H](O[*])[C@H](O)[C@@H](O)[C@H](O)[C@H]1(C(=O)O) |$;;;R$|
Commons category: Glucuronides

Sources (2)

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Article

5 sections

Contents

Classes of glucuronides
Acyl glucuronide
N<sup>+</sup>-glucuronide
Examples
References

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.