GPR25

Also known as G protein-coupled receptor 25

Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.

In the Vinony graph

Within Vinony's link graph, GPR25 is referenced by 3 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

It sits within the topics Chemokine receptors, Genes on human chromosome 1 and G protein-coupled receptors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

GPR25

Name: G protein-coupled receptor 25
Type: protein-coding
Position: 200,872,981–200,874,178 (+)
Ensembl: ENSG00000170128
RefSeq RNA: NM_005298.4
RefSeq protein: NP_005289.2

This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway leukocyte chemotaxis lymphocyte chemotaxis chemokine-mediated signaling pathway lymphocyte migration into lymphoid organs

Molecular function

G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity G protein-coupled receptor activity protein binding C-X-C chemokine receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane

Pathways

Signal Transduction Signaling by GPCR GPCR downstream signalling G alpha (s) signalling events GPCRs, Class A Rhodopsin-like

via MyGene.info

Gene · Ensembl

G protein-coupled receptor 25

Symbol: GPR25
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:200,872,981-200,874,178
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2848
HomoloGene ID: 3872
genomic end: 200843306
genomic start: 200872981
chromosome: human chromosome 1
cytogenetic location: 1q32.1
expressed in: face

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Structure
Tissue distribution
Function
References
Further reading

Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.

== Structure == It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.

Excerpted from Wikipedia’s “GPR25” article, available under the CC BY-SA 4.0 licence.