GPR161
Sign in to saveAlso known as RE2, G protein-coupled receptor 161
G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.
In the Vinony graph
Within Vinony's link graph, GPR161 is referenced by 485 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
It sits within the topics Genes on human chromosome 1 and G protein-coupled receptors.
Its subject is documented across 5 Wikipedia language editions.
Gene data
GPR161- Name
- G protein-coupled receptor 161
- Type
- protein-coding
- Position
- 168,079,542–168,137,685 (−)
- Aliases
- RE2
- Ensembl
- ENSG00000143147
- RefSeq RNA
- NM_001267609.1, NM_001267610.2, NM_001267611.1, NM_001267612.2, NM_001267613.1
- RefSeq protein
- NP_001254538.1, NP_001254539.1, NP_001254540.1, NP_001254541.1, NP_001254542.1
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
G protein-coupled receptor 161
- Symbol
- GPR161
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:168,079,542-168,137,685
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 17824
- genomic end
- 168106821
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23432
- genomic start
- 168079542
- chromosome
- human chromosome 1
- cytogenetic location
- 1q24.2
- expressed in
- pars compacta
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.
==References==
Excerpted from Wikipedia’s “GPR161” article, available under the CC BY-SA 4.0 licence.