Also known as H963, G protein-coupled receptor 171
G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene. It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. It seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
~1 min read
G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene. It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. It seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.
==Ligands== Agonists BigLEN MS15203
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).