GPR171
Sign in to saveAlso known as H963, G protein-coupled receptor 171
G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene. It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. It seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.
In the Vinony graph
Within Vinony's link graph, GPR171 is referenced by 486 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
It sits within the topics Genes on human chromosome 3 and G protein-coupled receptors.
Its subject is documented across 5 Wikipedia language editions.
Gene data
GPR171- Name
- G protein-coupled receptor 171
- Type
- protein-coding
- Position
- 151,197,832–151,203,216 (−)
- Aliases
- H963
- Ensembl
- ENSG00000174946
- RefSeq RNA
- NM_013308.4, XM_005247402.4, XM_005247403.4, XM_047448054.1, XM_047448055.1
- RefSeq protein
- NP_037440.3, XP_005247459.1, XP_005247460.1, XP_047304010.1, XP_047304011.1
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
G protein-coupled receptor 171
- Symbol
- GPR171
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:151,197,832-151,203,216
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 36330
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29909
- genomic end
- 151203216
- genomic start
- 150915619
- chromosome
- human chromosome 3
- cytogenetic location
- 3q25.1
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Ligands
- References
- Further reading
G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene. It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. It seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.
==Ligands== Agonists BigLEN MS15203
Excerpted from Wikipedia’s “GPR171” article, available under the CC BY-SA 4.0 licence.