Structure via PubChem · Public domain (PubChem)
GR 89696
Sign in to saveAlso known as GR 85571, GR-103545, GR-89696
GR-89696 is a drug which acts as a highly selective κ-opioid agonist. It has been studied in various animal species, and has been described as selective for the κ2 subtype. Recent studies have suggested that GR-89696 and related κ2-selective agonists may be useful for preventing the itching which is a common side effect of conventional opioid analgesic drugs, without the additional side effects of non-selective kappa agonists. The structure bound to the κ-opioid receptor has been reported.
In the Vinony graph
Vinony's link graph records 693 inbound references to GR 89696, and connects out to (+)-catechin, butorphanol and OPRK1.
Vinony files it under 1-Pyrrolidinyl compounds, Acetamides and Chemical pages without DrugBank identifier.
Vinony links it to 4 Wikipedia language editions.
Chemical data
- Formula
- C19H25Cl2N3O3
- Molecular weight
- 414.3 g/mol
- IUPAC name
- methyl 4-[2-(3,4-dichlorophenyl)acetyl]-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate
- SMILES
- COC(=O)N1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
- InChIKey
- HJUAKZYKCANOOZ-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 53.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 413.127297
Show 3 more facts
- chemical formula
- C₁₉H₂₅Cl₂N₃O₃
- canonical SMILES
- COC(=O)N1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
- Commons category
- GR-89696
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
GR-89696 is a drug which acts as a highly selective κ-opioid agonist. It has been studied in various animal species, and has been described as selective for the κ2 subtype. Recent studies have suggested that GR-89696 and related κ2-selective agonists may be useful for preventing the itching which is a common side effect of conventional opioid analgesic drugs, without the additional side effects of non-selective kappa agonists. The structure bound to the κ-opioid receptor has been reported.
== References ==
Excerpted from Wikipedia’s “GR 89696” article, available under the CC BY-SA 4.0 licence.