HSPE1
Sign in to saveAlso known as heat shock 10kDa protein 1, CPN10, EPF, GROES, HSP10, heat shock protein family E (Hsp10) member 1
Heat shock 10 kDa protein 1 (Hsp10), also known as chaperonin 10 (cpn10) or early-pregnancy factor (EPF), is a protein that in humans is encoded by the HSPE1 gene. The homolog in E. coli is GroES that is a chaperonin which usually works in conjunction with GroEL.
Gene data
HSPE1- Name
- heat shock protein family E (Hsp10) member 1
- Type
- protein-coding
- Position
- 197,500,140–197,503,461 (+)
- Aliases
- CPN10, EPF, GROES, HSP10
- Ensembl
- ENSG00000115541
- RefSeq RNA
- NM_002157.3
- RefSeq protein
- NP_002148.1
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
heat shock protein family E (Hsp10) member 1
- Symbol
- HSPE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:197,500,110-197,513,408
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 20500
- exact match
- identifiers.org/ncbigene/3336
- genomic end
- 197503449
- genomic start
- 197500140
- cytogenetic location
- 2q33.1
via Wikidata · CC0
~7 min read
Article
12 sectionsContents
- Structure and function
- Interactions
- Detection
- Origin
- Clinical utility
- Pregnancy testing
- Birth control research
- Infertility and early pregnancy loss
- As a tumour marker
- References
- Further reading
- External links
Heat shock 10 kDa protein 1 (Hsp10), also known as chaperonin 10 (cpn10) or early-pregnancy factor (EPF), is a protein that in humans is encoded by the HSPE1 gene. The homolog in E. coli is GroES that is a chaperonin which usually works in conjunction with GroEL.
== Structure and function ==