HSPE1
Sign in to saveAlso known as heat shock 10kDa protein 1, CPN10, EPF, GROES, HSP10, heat shock protein family E (Hsp10) member 1
Heat shock 10 kDa protein 1 (Hsp10), also known as chaperonin 10 (cpn10) or early-pregnancy factor (EPF), is a protein that in humans is encoded by the HSPE1 gene. The homolog in E. coli is GroES that is a chaperonin which usually works in conjunction with GroEL.
In the Vinony graph
Within Vinony's link graph, HSPE1 is referenced by 129 other articles, and connects out to PubMed, pregnancy test and Ensembl genome database project.
It is catalogued under topics including Co-chaperones, Genes on human chromosome 2 and Moonlighting proteins.
Its subject is documented across 6 Wikipedia language editions.
Gene data
HSPE1- Name
- heat shock protein family E (Hsp10) member 1
- Type
- protein-coding
- Position
- 197,500,110–197,513,408 (+)
- Aliases
- CPN10, EPF, GROES, HSP10
- Ensembl
- ENSG00000115541
- RefSeq RNA
- NM_002157.3
- RefSeq protein
- NP_002148.1
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
heat shock protein family E (Hsp10) member 1
- Symbol
- HSPE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:197,500,110-197,513,408
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 20500
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3336
- genomic end
- 197503449
- genomic start
- 197500140
- chromosome
- human chromosome 2
- cytogenetic location
- 2q33.1
via Wikidata · CC0
~7 min read
Encyclopedic overview
12 sectionsContents
- Structure and function
- Interactions
- Detection
- Origin
- Clinical utility
- Pregnancy testing
- Birth control research
- Infertility and early pregnancy loss
- As a tumour marker
- References
- Further reading
- External links
Heat shock 10 kDa protein 1 (Hsp10), also known as chaperonin 10 (cpn10) or early-pregnancy factor (EPF), is a protein that in humans is encoded by the HSPE1 gene. The homolog in E. coli is GroES that is a chaperonin which usually works in conjunction with GroEL.
== Structure and function ==
Excerpted from Wikipedia’s “HSPE1” article, available under the CC BY-SA 4.0 licence.