IFNAR2
Sign in to saveAlso known as IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.
Gene data
IFNAR2- Name
- interferon alpha and beta receptor subunit 2
- Type
- protein-coding
- Position
- 33,205,282–33,265,675 (+)
- Aliases
- IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
- Ensembl
- ENSG00000159110
- RefSeq RNA
- NM_000874.5, NM_001289125.3, NM_001289126.2, NM_001289128.2, NM_001385054.1
- RefSeq protein
- NP_000865.2, NP_001276054.1, NP_001276055.1, NP_001276057.1, NP_001371983.1
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interferon alpha and beta receptor subunit 2
- Symbol
- IFNAR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:33,205,282-33,265,675
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein IFNAR2 PDB 1n6u.png
Show 5 more facts
- HomoloGene ID
- 49242
- exact match
- identifiers.org/ncbigene/3455
- genomic end
- 34637980
- genomic start
- 33205282
- cytogenetic location
- 21q22.11
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.
== Function ==