IFNAR2

Also known as IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.

Gene data

IFNAR2

Name: interferon alpha and beta receptor subunit 2
Type: protein-coding
Position: 33,205,282–33,265,675 (+)
Aliases: IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Ensembl: ENSG00000159110
RefSeq RNA: NM_000874.5, NM_001289125.3, NM_001289126.2, NM_001289128.2, NM_001385054.1
RefSeq protein: NP_000865.2, NP_001276054.1, NP_001276055.1, NP_001276057.1, NP_001371983.1

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020].