IL31RA

Also known as CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.

In the Vinony graph

Vinony's link graph records 8 inbound references to IL31RA, and connects out to PubMed, human chromosome 5 and Interleukin 2.

It is catalogued under the topic Genes on human chromosome 5.

Vinony links it to 6 Wikipedia language editions.

Gene data

IL31RA

Name: interleukin 31 receptor A
Type: protein-coding
Position: 55,851,357–55,922,854 (+)
Aliases: CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, zcytoR17
Ensembl: ENSG00000164509
RefSeq RNA: NM_001242636.2, NM_001242637.2, NM_001242638.2, NM_001242639.2, NM_001297570.3
RefSeq protein: NP_001229565.1, NP_001229566.1, NP_001229567.1, NP_001229568.1, NP_001284499.1

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)Cytokine Signaling in Immune system Immune System Signaling by Interleukins Interleukin-6 family signaling IL-6-type cytokine receptor ligand interactions

via MyGene.info

Gene · Ensembl

interleukin 31 receptor A

Symbol: IL31RA
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:55,851,357-55,922,854
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 51395
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/133396
genomic end: 55922854
genomic start: 55851357
chromosome: human chromosome 5
cytogenetic location: 5q11.2
expressed in: tibia

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]

Excerpted from Wikipedia’s “IL31RA” article, available under the CC BY-SA 4.0 licence.