KCNA3
Sign in to saveAlso known as HLK3, HGK5, HPCN3, HUKIII, KV1.3, MK3, PCN3, potassium voltage-gated channel subfamily A member 3
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene.
Gene data
KCNA3- Name
- potassium voltage-gated channel subfamily A member 3
- Type
- protein-coding
- Aliases
- HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
potassium voltage-gated channel subfamily A member 3
- Symbol
- KCNA3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:110,653,560-110,674,940
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein KCNA3 PDB 1dsx.png
Show 6 more facts
- HomoloGene ID
- 128570
- exact match
- identifiers.org/ncbigene/3738
- genomic start
- 111214310
- genomic end
- 110674940
- cytogenetic location
- 1p13.3
- Commons category
- Kv1.3 potassium channel
Sources (3)
via Wikidata · CC0
~7 min read
Article
9 sectionsContents
- Function
- Clinical significance
- Autoimmune
- Metabolic
- Neurodegeneration
- Blockers
- See also
- References
- External links
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s).