Also known as Kell Blood Group, CD238, Kell metallo-endopeptidase (Kell blood group), Kell Blood Group Glycoprotein, Kell blood group, metallo-endopeptidase, Kell Blood Group Antigen, EC 3.4.24, Kell Blood Group, Metalloendopeptidase
antigen system in humans which determines Kell blood type
Gene data
KEL- Name
- Kell metallo-endopeptidase (Kell blood group)
- Type
- protein-coding
- Position
- 142,941,114–142,962,363 (−)
- Aliases
- CD238, ECE3, Kell
- Ensembl
- ENSG00000276615
- RefSeq RNA
- NM_000420.3, XM_005249993.2, XM_047420357.1, XM_054328705.1, XM_054328706.1
- RefSeq protein
- NP_000411.1, XP_005250050.1, XP_047276313.1, XP_054184680.1, XP_054184681.1
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Kell metallo-endopeptidase (Kell blood group)
- Symbol
- KEL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR7_2_CTG6:964,181-985,748
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
1,393 papers- Five novel silenced KEL*02 alleles.Transfusion · 2021
- Genomic analysis of KEL*03 and KEL*04 alleles among Thai blood donors.African journal of laboratory medicine · 2024
- Novel KEL*02M allele in Austria encoding a K(mod) phenotype.Transfusion · 2022
- Use of KEL-1 negative red blood cells for emergency release.Transfusion · 2023
- Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia.Oxidative medicine and cellular longevity · 2022
via PubMed
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 362
- exact match
- identifiers.org/ncbigene/3792
- genomic end
- 142962363
- genomic start
- 142638201
- cytogenetic location
- 7q34
Sources (4)
via Wikidata · CC0