KPNA6

Also known as IPOA7, KPNA7, karyopherin subunit alpha 6

protein-coding gene in the species Homo sapiens

In the Vinony graph

Within Vinony's link graph, KPNA6 is referenced by 4 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under topics including Armadillo-repeat-containing proteins and Genes on human chromosome 1.

Its subject is documented across 5 Wikipedia language editions.

Gene data

KPNA6

Name: karyopherin subunit alpha 6
Type: protein-coding
Position: 32,108,028–32,176,563 (+)
Aliases: IPOA7
Ensembl: ENSG00000025800
RefSeq RNA: NM_012316.5, XM_005270711.4, XM_024446165.2, XM_024446166.2, XM_047416671.1
RefSeq protein: NP_036448.1, XP_005270768.1, XP_024301933.1, XP_024301934.1, XP_047272627.1

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008].