Structure via PubChem · Public domain (PubChem)
lesopitron
Sign in to saveAlso known as E-4424, Lesopitran
Lesopitron (E-4424) is a selective full agonist of the 5-HT1A receptor which is structurally related to the azapirones. In 2001 it was under development by Esteve as an anxiolytic for the treatment of generalized anxiety disorder (GAD). It made it to phase II clinical trials but was apparently discontinued as no new information on lesopitron has surfaced since.
In the Vinony graph
Vinony's link graph records 1,367 inbound references to lesopitron, and connects out to N-methylserotonin, agonist and monoamine oxidase inhibitor.
It sits within the topics Aminopyrimidines, Chemical pages without DrugBank identifier and Chloroarenes.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C15H21ClN6
- Molecular weight
- 320.82 g/mol
- IUPAC name
- 2-[4-[4-(4-chloropyrazol-1-yl)butyl]piperazin-1-yl]pyrimidine
- SMILES
- C1CN(CCN1CCCCN2C=C(C=N2)Cl)C3=NC=CC=N3
- InChIKey
- AHCPKWJUALHOPH-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 50.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 320.151622
Show 2 more facts
- chemical formula
- C₁₅H₂₁ClN₆
- canonical SMILES
- C1CN(CCN1CCCCN2C=C(C=N2)Cl)C3=NC=CC=N3
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
{{Drugbox | IUPAC_name = 2-{4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-yl}pyrimidine | image = Lesopitron.png | image_class = skin-invert-image
| tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral
Excerpted from Wikipedia’s “lesopitron” article, available under the CC BY-SA 4.0 licence.