Structure via PubChem · Public domain (PubChem)
fludiazepam
Sign in to saveAlso known as Erispan, 7-chloro-5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one, Fludiazepamum
Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffmann-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.
In the Vinony graph
Vinony's link graph records 695 inbound references to fludiazepam, and connects out to benzodiazepine drug, alphenal and validol.
It is catalogued under topics including 2-Fluorophenyl compounds, Anticonvulsants and Anxiolytics.
Vinony links it to 17 Wikipedia language editions.
Chemical data
- Formula
- C16H12ClFN2O
- Molecular weight
- 302.73 g/mol
- IUPAC name
- 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
- SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F
- InChIKey
- ROYOYTLGDLIGBX-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- anxiety
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 302.062219
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₆H₁₂ClFN₂O
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F
- Commons category
- Fludiazepam
- defined daily dose
- 0.75
- subject has role
- anxiolytic
- MCN code
- 2933.91.31
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffmann-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.
== See also == Diazepam Diclazepam (the 2ʹ-chloro analog) Difludiazepam (the 2',6'-difluoro derivative) Flunitrazepam (the 7-nitro analog) Flualprazolam (the triazolo derivative) Ro20-8552
Excerpted from Wikipedia’s “fludiazepam” article, available under the CC BY-SA 4.0 licence.