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dimdazenil
Sign in to saveAlso known as EVT-201, Junoenil
Dimdazenil, sold under the brand name Junoenil, is a medication used in the treatment of insomnia in China. It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABAA receptor with two- to four-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits.
In the Vinony graph
Vinony's link graph records 542 inbound references to dimdazenil, and connects out to amylene hydrate, benzodiazepine drug and 4-hydroxybutyric acid.
Vinony files it under Chloroarenes, Dimethylamino compounds and Drugs with non-standard legal status.
Vinony links it to 5 Wikipedia language editions.
Chemical data
- Formula
- C17H17ClN6O2
- Molecular weight
- 372.8 g/mol
- IUPAC name
- 7-chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
- SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C(=CC=C3)Cl)C4=NOC(=N4)CN(C)C
- InChIKey
- JCYLWUVDHLVGER-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 80.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- medication
- Mass
- 372.110151
Show 2 more facts
- chemical formula
- C₁₇H₁₇ClN₆O₂
- canonical SMILES
- CN1CC2=C(N=CN2C3=C(C1=O)C(=CC=C3)Cl)C4=NOC(=N4)CN(C)C
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Medical use
- History
- References
Dimdazenil, sold under the brand name Junoenil, is a medication used in the treatment of insomnia in China. It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABAA receptor with two- to four-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits.
==Medical use== Dimdazenil shows effectiveness in the treatment of insomnia, but has less intrinsic activity in comparison to currently-marketed benzodiazepines and the Z-drugs; however, it is thought that the lower efficacy may result in fewer side effects, such as motor incoordination. In China, dimdazenil is approved for short-term treatment of insomnia.
Excerpted from Wikipedia’s “dimdazenil” article, available under the CC BY-SA 4.0 licence.