English
Structure via PubChem · Public domain (PubChem)
terbogrel
Sign in to saveTerbogrel (INN) is an experimental drug that has been studied for its potential to prevent the vasoconstricting and platelet-aggregating action of thromboxanes. Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The drug was developed by Boehringer Ingelheim.
Chemical data
- Formula
- C23H27N5O2
- Molecular weight
- 405.5 g/mol
- IUPAC name
- (E)-6-[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
- SMILES
- CC(C)(C)N=C(NC#N)NC1=CC=CC(=C1)/C(=C\CCCC(=O)O)/C2=CN=CC=C2
- InChIKey
- XUTLOCQNGLJNSA-RGVLZGJSSA-N
- XLogP
- 4.2
- Polar surface area
- 110 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- pulmonary arterial hypertension
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 405.216
Show 4 more facts
- chemical formula
- C₂₃H₂₇N₅O₂
- isomeric SMILES
- CC(C)(C)N=C(NC#N)NC1=CC=CC(=C1)/C(=C\CCCC(=O)O)/C2=CN=CC=C2
- canonical SMILES
- CC(C)(C)N=C(NC#N)NC1=CC=CC(=C1)C(=CCCCC(=O)O)C2=CN=CC=C2
- Commons category
- Terbogrel
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470602217 | ImageFile = Terbogrel.svg | ImageSize = | IUPACName = (5E)-6-{3-[tert-Butyl(cyano)carbamimidamido]phenyl}-6-pyridin-3-ylhex-5-enoic acid | OtherNames = (5E)-6-[m-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5-hexenoic acid | Section1 = | Section2 = | Section3 = }}
Terbogrel (INN) is an experimental drug that has been studied for its potential to prevent the vasoconstricting and platelet-aggregating action of thromboxanes. Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The drug was developed by Boehringer Ingelheim.
Excerpted from Wikipedia’s “terbogrel” article, available under the CC BY-SA 4.0 licence.