MED14
Sign in to saveAlso known as CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.
In the Vinony graph
Within Vinony's link graph, MED14 is referenced by 9 other articles, and connects out to PubMed, Ensembl genome database project and enzyme.
It is catalogued under the topic Genes on human chromosome X.
Its subject is documented across 4 Wikipedia language editions.
Gene data
MED14- Name
- mediator complex subunit 14
- Type
- protein-coding
- Chromosome
- X
- Position
- 40,648,305–40,735,924 (−)
- Aliases
- CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
- Ensembl
- ENSG00000180182
- RefSeq RNA
- NM_004229.4, XM_047442636.1, XM_047442637.1, XM_047442638.1, XM_047442639.1
- RefSeq protein
- NP_004220.2, XP_047298592.1, XP_047298593.1, XP_047298594.1, XP_047298595.1
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
mediator complex subunit 14
- Symbol
- MED14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:40,648,305-40,735,924
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- The IDRc bound human core Mediator complex - Mediator of RNA polymerase II transcription subunit 14 8TRH.png
Show 7 more facts
- HomoloGene ID
- 22082
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9282
- chromosome
- human X chromosome
- genomic end
- 40595110
- genomic start
- 40648305
- cytogenetic location
- Xp11.4
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Excerpted from Wikipedia’s “MED14” article, available under the CC BY-SA 4.0 licence.