KLK14
Sign in to saveAlso known as KLK-L6, kallikrein related peptidase 14
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.
In the Vinony graph
Vinony's link graph records 143 inbound references to KLK14, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 6 Wikipedia language editions.
Gene data
KLK14- Name
- kallikrein related peptidase 14
- Type
- protein-coding
- Position
- 51,077,317–51,086,530 (−)
- Aliases
- KLK-L6
- Ensembl
- ENSG00000129437
- RefSeq RNA
- NM_001311182.2, NM_001369775.2, NM_022046.6, NR_163144.1, XM_017026820.2
- RefSeq protein
- NP_001298111.2, NP_001356704.1, NP_071329.3, XP_016882309.1, XP_054177022.1
This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
kallikrein related peptidase 14
- Symbol
- KLK14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:51,077,317-51,086,530
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 69348
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/43847
- genomic end
- 51587502
- genomic start
- 51580752
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.41
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer, skin disorders and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Apart from its common transcript, an additional transcript variant has been described but its difference in function and full length nature has not been determined.
Excerpted from Wikipedia’s “KLK14” article, available under the CC BY-SA 4.0 licence.