methantheline

Chemical data

Formula

C21H26NO3+

Molecular weight

340.4 g/mol

IUPAC name

diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium

SMILES

CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13

InChIKey

GZHFODJQISUKAY-UHFFFAOYSA-N

XLogP

3.3

Polar surface area

35.5 Ų

H-bond donors

0

H-bond acceptors

3

Formal charge

1

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1951

Admin. routes

oral

Indications

Neurogenic bladder, gastrointestinal disease

via ChEMBL · EBI

• Relative bioavailability and pharmacodynamic effects of methantheline compared with atropine in healthy subjects.European journal of clinical pharmacology · 2012
• Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro.Archives of toxicology · 1995
• Efficacy and safety of methantheline bromide (Vagantin(®) ) in axillary and palmar hyperhidrosis: results from a multicenter, randomized, placebo-controlled trial.Journal of the European Academy of Dermatology and Venereology : JEADV · 2013
• Excitation of Mytilus smooth muscle.The Journal of physiology · 1967
• METHANTHELINE bromide, banthine bromide (searle); beta-diethylmethylaminoethyl 9-xanthenecarboxylate bromide.Minnesota medicine · 1953

via PubMed

Wikidata facts

Subclass of

chemical compound

Mass

340.191269

Has use

medication

via Wikidata · CC0