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metomidate
Sign in to saveMetomidate is a non-barbiturate imidazole that was discovered by Janssen Pharmaceutica in 1965 and under the names (Hypnodil, Nokemyl) is sold as a sedative-hypnotic drug used in Europe to treat humans and for veterinary purposes.
In the Vinony graph
Vinony's link graph records 631 inbound references to metomidate, and connects out to benzodiazepine drug, isovaleric acid and allopregnanolone.
Vinony files it under 11β-Hydroxylase inhibitors, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C13H14N2O2
- Molecular weight
- 230.26 g/mol
- IUPAC name
- methyl 3-(1-phenylethyl)imidazole-4-carboxylate
- SMILES
- CC(C1=CC=CC=C1)N2C=NC=C2C(=O)OC
- InChIKey
- FHFZEKYDSVTYLL-UHFFFAOYSA-N
- XLogP
- 2.7
- Polar surface area
- 44.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
181 papers- (11)C-metomidate PET in the diagnosis of adrenal masses and primary aldosteronism: a review of the literature.Endocrine · 2020
- [(11)C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial.Nature medicine · 2023
- Metomidate-based imaging of adrenal masses.Hormones & cancer · 2011
- Lateralization in (11) C-Metomidate PET and outcome of adrenalectomy in primary aldosteronism.Endocrinology, diabetes & metabolism · 2022
- The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review.CNS drugs · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 230.106
Show 2 more facts
- canonical SMILES
- CC(C1=CC=CC=C1)N2C=NC=C2C(=O)OC
- chemical formula
- C₁₃H₁₄N₂O₂
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Metomidate is a non-barbiturate imidazole that was discovered by Janssen Pharmaceutica in 1965 and under the names (Hypnodil, Nokemyl) is sold as a sedative-hypnotic drug used in Europe to treat humans and for veterinary purposes.
11C-labelled metomidate (11C-metomidate), may be used with positron emission tomography (PET). For instance, to detect tumors of adrenocortical origin.
Excerpted from Wikipedia’s “metomidate” article, available under the CC BY-SA 4.0 licence.