Structure via PubChem · Public domain (PubChem)
nabumetone
Sign in to saveAlso known as BRL-14777, 4-(6-methoxy-2-naphthalenyl)-2-butanone, 4-(6-methoxy-2-naphthyl)-2-butanone
class=skin-invert-image|thumb|Three step CYP1A2 Mediated Metabolism of the prodrug Nabumetone to its active metabolite 6-MNA.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 462258056
- Drug.image
- Nabumetone.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Relafen
- Drug.MedlinePlus
- a692022
- Drug.DailyMedID
- Nabumetone
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- M01
- Drug.ATC_suffix
- AX01
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.protein_bound
- > 99% (active metabolite)
- Drug.metabolism
- Liver, to active metabolite 6-methoxy-2-naphthylacetic acid; 6-MNA
- Drug.elimination_half life
- 23 hours (active metabolite)
- Drug.excretion
- Kidney
- Drug.CAS_number
- 42924-53-8
via Wikipedia infobox
Chemical data
- Formula
- C15H16O2
- Molecular weight
- 228.29 g/mol
- IUPAC name
- 4-(6-methoxynaphthalen-2-yl)butan-2-one
- SMILES
- CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC
- InChIKey
- BLXXJMDCKKHMKV-UHFFFAOYSA-N
- XLogP
- 3.1
- Polar surface area
- 26.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
531 papers- Nabumetone.2006
- Nabumetone.2012
- [Nabumetone].Revista de medicina de la Universidad de Navarra · 1995
- Nabumetone (Relifex)--another NSAID.Drug and therapeutics bulletin · 1988
- Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis.Drugs · 2004
via PubMed
Wikidata facts
- Subclass of
- non-steroidal anti-inflammatory drug
- Mass
- 228.115
- Has use
- medication
Show 10 more facts
- Commons category
- Nabumetone
- legal status (medicine)
- boxed warning
- medical condition treated
- osteoarthritis
- chemical formula
- C₁₅H₁₆O₂
- canonical SMILES
- CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC
- World Health Organisation international non-proprietary name
- nabumetone
- defined daily dose
- 1
- subject has role
- COX-2 inhibitor
- MCN code
- 2914.50.10
- significant drug interaction
- tacrolimus
Sources (7)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Medical uses
- Side effects
- Society and culture
- Brand names
- References
class=skin-invert-image|thumb|Three step CYP1A2 Mediated Metabolism of the prodrug Nabumetone to its active metabolite 6-MNA.
Nabumetone, sold under the brand name Relafen among others, is a nonsteroidal anti-inflammatory drug (NSAID). Nabumetone was developed by Beecham and first received regulatory approval in 1991.
Excerpted from Wikipedia’s “nabumetone” article, available under the CC BY-SA 4.0 licence.