NISCH
Sign in to saveAlso known as I-1, IR1, IRAS, hIRAS, nischarin
Nischarin is a protein that in humans is encoded by the NISCH gene.
In the Vinony graph
Within Vinony's link graph, NISCH is referenced by 4 other articles, and connects out to PubMed, human chromosome 3 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 3.
Its subject is documented across 5 Wikipedia language editions.
Gene data
NISCH- Name
- nischarin
- Type
- protein-coding
- Position
- 52,455,118–52,493,081 (+)
- Aliases
- I-1, IR1, IRAS, hIRAS
- Ensembl
- ENSG00000010322
- RefSeq RNA
- NM_001276293.2, NM_001276294.2, NM_007184.4, XM_006712955.4, XM_047447373.1
- RefSeq protein
- NP_001263222.2, NP_001263223.2, NP_009115.3, XP_006713018.1, XP_047303329.1
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
nischarin
- Symbol
- NISCH
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:52,455,118-52,493,081
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 130564
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11188
- genomic end
- 52493068
- genomic start
- 52489134
- chromosome
- human chromosome 3
- cytogenetic location
- 3p21.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
Nischarin is a protein that in humans is encoded by the NISCH gene.
== Function == This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane as well as early and recycling endosome membranes. It is a scaffold protein related to Sorting nexins and it regulates protein cargo traffic. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.
Excerpted from Wikipedia’s “NISCH” article, available under the CC BY-SA 4.0 licence.