OGN

Also known as OG, OIF, SLRR3A, osteoglycin

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.

Gene data

OGN

Name: osteoglycin
Type: protein-coding
Position: 92,383,268–92,406,734 (−)
Aliases: OG, OIF, SLRR3A
Ensembl: ENSG00000291350
RefSeq RNA: NM_014057.5, NM_024416.4, NM_033014.4
RefSeq protein: NP_054776.1, NP_077727.3, NP_148935.1

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

Gene Ontology

Biological process

negative regulation of smooth muscle cell proliferation bone development

Article

2 sections

Contents

References
Further reading

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.